Enterocytes turn over every 3-5 days. L-Glutamine provides the energy required for this rapid regeneration. High-dose supplementation (5-10g+) has been shown to significantly reduce intestinal permeability triggered by stress or infection.

Since up to 70% of systemic inflammation originates from the gut ("Metabolic Endotoxemia"), sealing the gut lining is priority #1. Glutamine fuels the repair of enterocytes, preventing LPS from leaking into the blood.

Endotoxemia (LPS in the blood) triggers an immune response 100x stronger than most food sensitivities. By fueling the rapid turnover of gut lining cells, Glutamine shuts this "toxic valve," quieting the immune system system-wide.