Overview
For some individuals (APOE4 carriers or "Lean Mass Hyper-Responders"), saturated fat dramatically downregulates LDL receptors, causing massive spikes in LDL. Replacing butter/coconut oil with monounsaturated fats (olive oil) can crash LDL levels in these cases.
Health Goals Impacted 1
This item supports, tracks, or is required for the following health goals:
Targeted intervention for hyper-absorbers.
Saturated fat intake downregulates the SREBP-2 pathway, telling the liver "we have enough lipid energy," which causes it to reduce the number of LDL receptors on its surface. This leaves LDL particles circulating in the blood longer.
For sensitive individuals (Hyper-responders), replacing butter/coconut oil with Monounsaturated Fats (Olive/Macadamia) can double the lifespan of LDL receptors and crash ApoB levels rapidly.